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XL-C30
XINGLE
In modern pharmaceutical manufacturing, the liquid vial filling and capping integrated machine has become the core equipment for sterile parenteral production lines. This advanced vial filling machine integrates filling, stopper insertion, and crimping into a single platform, operating under Grade A laminar airflow protection to achieve fully automatic aseptic filling. It is widely used in vaccines, biologics, chemical drug injections, and high-value liquid products.
According to the Technical Specification for Precision Filling Systems of Vial Filling Machines ,the filling measurement error must be ≤ ±2%. Mainstream integrated machines utilize peristaltic pump or piston pump metering systems.The filling accuracy can reach ±0.5% or better, far exceeding standard requirements. Ensure consistent dosing per vial, significantly reducing wastage of high-value drug solutions.
The integrated machine is designed from the ground up with a full aseptic philosophy:
Laminar Flow Protection: Filling, stopper insertion, and crimping are all performed under Grade A laminar airflow, with first-pass laminar protection.
Nitrogen Blanketing: For oxygen-sensitive drugs, the equipment incorporates triple nitrogen purging (pre-fill, post-fill, and during stoppering), capable of controlling residual oxygen levels to ≤ 2%.
The integrated machine consolidates vial sorting, filling, stoppering, and crimping into one unified platform, with full automatic control via a PLC and touchscreen HMI. Key automated functions include:
No-bottle-no-fill and no-stopper-no-cap logic to prevent material waste.
Servo-driven mechanisms ensuring precise synchronization across all stations; high-speed models can achieve outputs of up to 1200 vials per hour.
The integrated machine handles 2 mL to 500 mL vials, compatible with COP (cycloolefin polymer), glass, and other materials. It is suitable for liquids, lyophilized formulations, oily products, and high-viscosity substances. Advanced models support tool-free format changeover, greatly enhancing flexibility for multi-product, small-batch operations.
| Application Field | Typical Products | Key Requirements |
| Biopharmaceuticals | Monoclonal antibodies, vaccines, cell therapies | Aseptic assurance, high precision, low-temperature filling |
| Chemical Drug Injections | Antibiotics, aqueous injections, lyophilized powder precursors | Production capacity, GMP compliance |
| Aesthetic Medicine / Skincare | Hyaluronic acid, collagen, essential oils | High-viscosity filling, micro-dosing accuracy |
| iagnostic Reagents | Liquid reagents, calibrators | Small batches, rapid multi-spec changeover |
Cartridge bottle filling machine is widely used in the production line of cassette bottle products in various industries such as pharmaceutical, cosmetic, beverage, daily chemical and so on.
When procuring a liquid vial filling and capping integrated machine, pharmaceutical companies should pay close attention to the following aspects:
Regulatory Compliance: Does the equipment meet cGMP, EU GMP, FDA 21 CFR Part 11 requirements? Can the vendor supply a complete validation documentation package?
Filling Accuracy vs. Speed: Based on product formulation and annual capacity, choose the appropriate pump system (peristaltic or piston pump) and the optimal number of filling heads.
Aseptic Assurance Level: Does the equipment require isolator integration? Is CIP/SIP supported? Is nitrogen blanketing fully implemented?
Changeover Efficiency: For multi-product environments, how fast and easy is mold changeover? Is tool-free conversion available?
